During the second wave of Covid-19 in India, Irfan and his brother Yusuf have been assisting the poor with food, oxygen cylinders, ventilators and oxygen concentrators. The donation is made through the Pathan Foundation, which is run by the brothers.
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Irfan has also been involved on Twitter, where he has expressed his views on issues such as Palestine. He also retweeted a few tweets about the topic from international cricketers. Kangana Ranaut, a Bollywood star, chastised him for his tweet on Palestine.
Irfan had previously contracted the virus following the Road Safety World Series 2020-21. He was asymptomatic at the time and was able to recover at home. He appeared in seven games and took seven wickets while scoring 126 runs in three innings. He was successful in helping India Legends win by 14 runs in the tournament final, taking two wickets against Sri Lanka Legends.