In the first, teenage sisters Jade and Billie Wesker move to New Raccoon City, a prefab corporate town, along with their father Albert, who is a top scientist at Umbrella. A bit by bit, they begin to discover disturbing secrets related to their father, his creation and the evil company behind it all.
While the second timeline takes place a decade later when the T-Virus has infected most people and Jade tries to find a way to fix the mistakes her father made. However, in the process, she makes her own mistakes and puts her loved ones at risk.
After losing her job for six months, the protagonist of " Resident Evil " is captured by a gang of scavengers who intend to hand her over to Umbrella. When the trade goes wrong, Jade takes advantage of the chaos to escape and seek out an old friend to help her get back home.
Although he does not get the support he hoped for, he manages to find transport, however, he is left at the mercy of the deranged leader of the Brotherhood. Thanks to the intervention of Baxter, who was sent by the company led by Evelyn Marcus, he manages to escape and find a possible solution to the virus.
In the past, Jade and Billie infiltrate the Umbrella facility to rescue some animals but find an infected dog that bites Billie. Although her father helps them escape and eliminates all the evidence, he cannot prevent her daughter from starting to show worrying symptoms.
However, the transformation never comes, probably due to the modified DNA of the teenager, who was created by Albert. However, after speaking with a reporter, the sisters decide to investigate further and find terrifying secrets from Umbrella and her father.
Meanwhile, Albert gets rid of the journalist but is discovered by Evelyn, who does not hesitate to use all her weapons to get him to continue working at Joy. Finally, her daughters learn that her father is a clone who created them to ensure their survival.
After the shocking reunion with Billie, Jade finds a way to return to her family. Although her sister still works for Umbrella, she assured him that she is dying and that she just wanted to say goodbye to her before the virus finally wipes her out.
Back with her family, the protagonist of "Resident Evil" analyzes the head of the zombie leader and, together with her friend Amrita, discovers that she can isolate two enzymes: one that motivates the attack of the infected and another that prevents it. Both agree to do the corresponding tests, but Jade does not seem willing to wait for the authorization and works on her own.
The experiment goes wrong and ends with several deaths, including Amrita, in addition, Umbrella arrives at the ship and demands that they hand over Jade in exchange for not destroying the place.
When Jade appears before Evelyn, she discovers that she is only a puppet controlled by Billie, who implanted a chip in her brain that allows her to control herself at will. What does he need Jade for? She requires her blood to control the virus that continues in her body.
To escape her sister, Jade uses her discovery, attracting a large number of infected and taking advantage of the chaos to return to the ship and press the red button, which sends a huge monster after Billie.
The problem is Bea escaped as her mother told her and is in danger. Although the little girl manages to escape, or control? the monster, Billie finds her, shoots her mother and takes her away. What will Jade do to get her back? What is Billie planning to do with her niece? What happened to Evelyn? When and why did the Wesker sisters break up? What is the creature that came out of the rubble?